A Human Disease Breaks out Across a Large Region of the World, is Known as
Option 1 ( Pandemic ) is the right answer.
A pandemic is an epidemic of infectious disease that has spread through human populations across a large region; for instance multiple continents, or even worldwide.
A widespread endemic disease that is stable in terms of how many people are getting sick from it is not a pandemic. Further, flu pandemics generally exclude recurrences of seasonal flu. Throughout history there have been a number of pandemics, such as smallpox and tuberculosis. More recent pandemics include the HIV pandemic as well as the 1918 and 2009 H1N1 pandemics. The Black Death was a devastating pandemic, killing over 75 million people.